Neuro-SAVE-ICU

Neuroimaging, Cognitive and Psychiatric outcomes in the SAVE-ICU trial (Neuro-SAVE-ICU) is prospective cohort sub-study of the SAVE-ICU RCT that aims to compare neuroimaging, cognitive and psychiatric outcomes in critically ill patients receiving inhaled volatile anesthetic-based sedation regimen versus standard/usual care intravenous sedation regimen within SAVE-ICU RCT. Neuro-SAVE-ICU team merges expertise of cognitive neuroscientists, neurologists, neuroradiologists, imaging scientists, intensivists, anesthesiologists and clinical research methodologists and state of the art methods to compare the effects of inhaled vs intravenous sedatives on brain structure and long-term neurocognitive function. The study uses novel state-of-the-art web-based neurocognitive battery, Cambridge Brain Sciences that will enable remote longitudinal assessment of neurocognitive outcomes in participants. Given that psychiatric morbidity can impact neurocognitive outcomes, we will also assess patients for symptoms of depression, anxiety, and post-traumatic stress disorder. In a sub-set of patients, we will also use MRI to compare structural brain changes in participants randomized to inhaled vs. intravenous arms.

Marat Slessarev

Adrian Owen

Angela Jerath

Brian Cuthbertson

Matylda Machnowska

Michael Jurkiewicz

Rachel Wagner

Udunna Anazodo

Coming soon