EEG-SAVE-ICU

Assessing brain network reconfiguration upon changes in sedation (EEG-SAVE-ICU) is a prospective pilot cohort feasibility sub-study of the SAVE-ICU RCT that aims to assess the feasibility of collecting EEG data before, during and after an interruption of sedation (either intravenous or volatile anesthetic) in ventilated critically ill patients for the purpose of calculating the brain network reconfiguration using the Adaptive Reconfiguration Index (ARI) of the patient’s brain networks and other brain networks measures. ARI and other brain network measures (e.g. directed functional connectivity, network hub location) are promising functional markers of brain’s ability to recover awareness when sedation is weaned. This information would be useful to guide complex sedation care, prognosticate conscious recovery levels and even longer-term neurocognitive and functional outcomes. Further, given that there is supportive evidence that volatile agents promote faster return of consciousness, assessing the utility of markers of brain network reconfiguration provides a practical bedside technique that can be used by clinicians in patient care.

Catherine Duclos

Stefanie Blain-Moraes

Marat Slessarev

Angela Jerath

Coming soon