Study summary
Economic Evaluation Alongside SAVE-ICU (E-SAVE-ICU) is an embedded sub-study of SAVE-ICU RCT that aims to evaluate the comparative cost-effectiveness of inhaled volatile anesthetic-based sedation regimen versus standard/usual care intravenous sedation regimen for critically ill patients. The primary objective of e-SAVE-ICU is to estimate the incremental cost per quality-adjusted life-years (QALY) arising from using inhaled volatile anesthetic (intervention arm) versus IV anesthetic (standard of care arm) during mechanical ventilation of critically ill patients. The secondary objectives are to estimate the incremental cost-effectiveness ratios (ICERs) of cost per life-year gained and cost per mortality averted. This study will use data collected from the SAVE-ICU RCT and link it to data available in Ontario’s provincial healthcare database in 10 centres across Canada
Study publications
Coming soon
